{"id":100,"date":"2022-10-18T05:59:45","date_gmt":"2022-10-17T22:59:45","guid":{"rendered":"http:\/\/demo.giraf.vn\/?p=100"},"modified":"2023-01-09T13:22:46","modified_gmt":"2023-01-09T06:22:46","slug":"lan-dau-tien-benh-di-truyen-ve-tim-co-the-duoc-chua-khoi","status":"publish","type":"post","link":"https:\/\/timbamsinhtphcm.vn\/en\/lan-dau-tien-benh-di-truyen-ve-tim-co-the-duoc-chua-khoi\/","title":{"rendered":"L\u1ea7n \u0111\u1ea7u ti\u00ean b\u1ec7nh di truy\u1ec1n v\u1ec1 tim c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1eefa kh\u1ecfi"},"content":{"rendered":"

V\u1edbi kho\u1ea3n t\u00e0i tr\u1ee3 tr\u1ecb gi\u00e1 30 tri\u1ec7u b\u1ea3ng Anh, m\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc \u1edf Anh, M\u1ef9 v\u00e0 Singapore \u0111ang h\u1ee3p l\u1ef1c nghi\u00ean c\u1ee9u \u0111\u1ec3 t\u1ea1o ra m\u1ed9t m\u0169i ti\u00eam c\u00f3 kh\u1ea3 n\u0103ng \u201cvi\u1ebft l\u1ea1i\u201d DNA v\u00e0 c\u1ee9u s\u1ed1ng h\u00e0ng ng\u00e0n ng\u01b0\u1eddi tr\u00ean th\u1ebf gi\u1edbi.<\/strong><\/p>\n

Ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb \u0111\u1ea7u ti\u00ean cho b\u1ec7nh di truy\u1ec1n v\u1ec1 tim n\u00e0y \u0111\u01b0\u1ee3c cho l\u00e0 s\u1ebd t\u1ea1o ra \u201cth\u1eddi kh\u1eafc quy\u1ebft \u0111\u1ecbnh\u201d \u0111\u1ed1i v\u1edbi l\u0129nh v\u1ef1c y h\u1ecdc v\u1ec1 tim m\u1ea1ch.<\/p>\n

Theo \u0111\u00f3, nh\u00f3m nghi\u00ean c\u1ee9u s\u1ebd l\u1ea7n \u0111\u1ea7u ti\u00ean s\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt di truy\u1ec1n ch\u00ednh x\u00e1c, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \u201cbase editing\u201d (ch\u1ec9nh s\u1eeda c\u01a1 b\u1ea3n) v\u00e0 \u201cprime editing\u201d (ch\u1ec9nh s\u1eeda \u1edf m\u1ee9c cao), \u0111\u1ed1i v\u1edbi tim \u0111\u1ec3 thi\u1ebft k\u1ebf v\u00e0 th\u1eed nghi\u1ec7m ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb \u0111\u1ea7u ti\u00ean cho c\u00e1c b\u1ec7nh c\u01a1 tim di truy\u1ec1n. M\u1ee5c \u0111\u00edch c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p n\u00e0y l\u00e0 ng\u0103n ch\u1eb7n s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a nh\u1eefng gene b\u1ecb l\u1ed7i trong tim. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt c\u0169ng \u0111\u00e3 cho th\u1ea5y hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c k\u1ef9 thu\u1eadt n\u00e0y. “\u0110\u00e2y l\u00e0 th\u1eddi kh\u1eafc quy\u1ebft \u0111\u1ecbnh \u0111\u1ed1i v\u1edbi l\u0129nh v\u1ef1c y h\u1ecdc tim m\u1ea1ch”, theo gi\u00e1o s\u01b0 Nilesh Samani \u2013 gi\u00e1m \u0111\u1ed1c y khoa c\u1ee7a Qu\u1ef9 Tim m\u1ea1ch Anh \u2013 t\u1ed5 ch\u1ee9c \u0111\u00e3 t\u00e0i tr\u1ee3 kinh ph\u00ed cho nh\u00f3m nghi\u00ean c\u1ee9u.<\/p>\n

C\u00e1c b\u1ec7nh c\u01a1 tim di truy\u1ec1n b\u1eaft ngu\u1ed3n t\u1eeb nhi\u1ec1u b\u1ea5t th\u01b0\u1eddng kh\u00e1c nhau \u1edf tr\u00e1i tim, song ch\u00fang c\u00f3 th\u1ec3 khi\u1ebfn ng\u01b0\u1eddi b\u1ec7nh \u0111\u1ed9t t\u1eed ho\u1eb7c m\u1eafc ch\u1ee9ng suy tim ti\u1ebfn tri\u1ec3n. Ch\u1ec9 ri\u00eang \u1edf Anh, \u0111\u00e3 c\u00f3 kho\u1ea3ng 260,000 ng\u01b0\u1eddi g\u1eb7p ph\u1ea3i t\u00ecnh tr\u1ea1ng b\u1ec7nh tim n\u00e0y. Kh\u00f4ng ch\u1ec9 v\u1eady, m\u1ed7i tu\u1ea7n \u1edf Anh c\u0169ng c\u00f3 12 ng\u01b0\u1eddi d\u01b0\u1edbi 35 tu\u1ed5i t\u1eed vong v\u00ec nh\u1eefng b\u1ec7nh tim ch\u01b0a \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n, trong \u0111\u00f3, nguy\u00ean nh\u00e2n th\u01b0\u1eddng g\u1eb7p l\u00e0 b\u1ec7nh c\u01a1 tim di truy\u1ec1n.<\/p>\n

\u0110i\u1ec1u \u0111\u00e1ng lo ng\u1ea1i l\u00e0 t\u1ea5t c\u1ea3 nh\u1eefng ng\u01b0\u1eddi m\u1eafc c\u0103n b\u1ec7nh n\u00e0y \u0111\u1ec1u c\u00f3 50\/50 nguy c\u01a1 truy\u1ec1n c\u00e1c gene b\u1ecb l\u1ed7i cho m\u1ed7i \u0111\u1ee9a con c\u1ee7a m\u00ecnh. V\u00e0 kh\u00f4ng \u00edt gia \u0111\u00ecnh \u0111\u00e3 c\u00f3 nhi\u1ec1u th\u00e0nh vi\u00ean c\u00f9ng m\u1eafc b\u1ec7nh suy tim, c\u1ea7n gh\u00e9p tim ho\u1eb7c ch\u1ebft khi c\u00f2n tr\u1ebb.<\/p>\n

Theo gi\u00e1o s\u01b0 Hugh Watkins (\u0110\u1ea1i h\u1ecdc Oxford) \u2013 nghi\u00ean c\u1ee9u vi\u00ean ch\u00ednh c\u1ee7a d\u1ef1 \u00e1n CureHeart, b\u1ec7nh c\u01a1 tim \u201cth\u1ef1c s\u1ef1 ph\u1ed5 bi\u1ebfn\u201d v\u00e0 c\u1ee9 250 ng\u01b0\u1eddi tr\u00ean kh\u1eafp th\u1ebf gi\u1edbi th\u00ec l\u1ea1i c\u00f3 m\u1ed9t ng\u01b0\u1eddi m\u1eafc ph\u1ea3i c\u0103n b\u1ec7nh nguy hi\u1ec3m \u1ea5y.<\/p>\n

Do \u0111\u00f3, m\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 \u0111\u01b0\u1ee3c th\u00e0nh l\u1eadp v\u1edbi s\u1ef1 l\u1ef1a ch\u1ecdn c\u1ee7a ban c\u1ed1 v\u1ea5n do gi\u00e1o s\u01b0 Patrick Vallance \u2013 c\u1ed1 v\u1ea5n khoa h\u1ecdc tr\u01b0\u1edfng c\u1ee7a ch\u00ednh ph\u1ee7 V\u01b0\u01a1ng qu\u1ed1c Anh \u2013 \u0111\u1ee9ng \u0111\u1ea7u.”\u201cD\u1ef1 \u00e1n n\u00e0y l\u00e0 c\u01a1 h\u1ed9i v\u00f4 c\u00f9ng hi\u1ebfm c\u00f3 \u0111\u1ec3 ch\u00fang t\u00f4i c\u00f3 th\u1ec3 t\u00ecm ra gi\u1ea3i ph\u00e1p ch\u1eefa tr\u1ecb, gi\u00fap xoa d\u1ecbu n\u1ed7i lo l\u1eafng c\u1ee7a nhi\u1ec1u gia \u0111\u00ecnh v\u1ec1 nh\u1eefng c\u00e1i ch\u1ebft \u0111\u1ed9t ng\u1ed9t hay nguy c\u01a1 ph\u1ea3i c\u1ea5y gh\u00e9p tim”, \u00f4ng n\u00f3i. “Sau 30 n\u0103m nghi\u00ean c\u1ee9u, ch\u00fang t\u00f4i \u0111\u00e3 ph\u00e1t hi\u1ec7n ra nhi\u1ec1u gene v\u00e0 c\u00e1c l\u1ed7i di truy\u1ec1n c\u1ee5 th\u1ec3 g\u00e2y ra c\u00e1c b\u1ec7nh c\u01a1 tim c\u0169ng nh\u01b0 c\u00e1ch m\u00e0 ch\u00fang ho\u1ea1t \u0111\u1ed9ng. B\u1edfi v\u1eady, ch\u00fang t\u00f4i tin r\u1eb1ng trong 5 n\u0103m t\u1edbi, ch\u00fang t\u00f4i s\u1ebd c\u00f3 th\u1ec3 c\u00f3 m\u1ed9t li\u1ec7u ph\u00e1p gene s\u1eb5n s\u00e0ng \u0111\u1ec3 b\u1eaft \u0111\u1ea7u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng”.<\/p>\n

Theo ch\u01b0\u01a1ng tr\u00ecnh nghi\u00ean c\u1ee9u m\u1edbi, c\u00e1c chuy\u00ean gia hy v\u1ecdng s\u1ebd c\u00f3 th\u1ec3 \u201cs\u1eeda ch\u1eefa\u201d v\u0129nh vi\u1ec5n ho\u1eb7c ng\u0103n ch\u1eb7n s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c gene \u0111\u1ed9t bi\u1ebfn g\u00e2y ra b\u1ec7nh tim.
\nChristine Seidman \u2013 gi\u00e1o s\u01b0 y khoa t\u1ea1i Tr\u01b0\u1eddng Y Harvard (M\u1ef9) v\u00e0 l\u00e0 \u0111\u1ed3ng tr\u01b0\u1edfng d\u1ef1 \u00e1n CureHeart \u2013 cho bi\u1ebft, \u00fd t\u01b0\u1edfng c\u1ee7a nh\u00f3m nghi\u00ean c\u1ee9u l\u00e0 t\u00ecm ra gi\u1ea3i ph\u00e1p \u0111\u1ec3 \u201cs\u1eeda tr\u00e1i tim\u201d v\u00e0 \u0111\u01b0a ch\u00fang tr\u1edf l\u1ea1i ho\u1ea1t \u0111\u1ed9ng b\u00ecnh th\u01b0\u1eddng.<\/p>\n

“M\u1eb7c d\u00f9 c\u00f3 r\u1ea5t nhi\u1ec1u \u0111\u1ed9t bi\u1ebfn kh\u00e1c nhau, nh\u01b0ng h\u1ea7u h\u1ebft c\u00e1c \u0111\u1ed9t bi\u1ebfn m\u00e0 ch\u00fang t\u00f4i t\u00ecm th\u1ea5y \u1edf b\u1ec7nh nh\u00e2n c\u1ee7a m\u00ecnh th\u01b0\u1eddng ch\u1ec9 l\u00e0m thay \u0111\u1ed5i m\u1ed9t k\u00fd t\u1ef1 duy nh\u1ea5t c\u1ee7a m\u00e3 DNA”, b\u00e0 n\u00f3i. “Nh\u1edd \u0111i\u1ec1u n\u00e0y, vi\u1ec7c thay \u0111\u1ed5i m\u1ed9t k\u00fd t\u1ef1 v\u00e0 kh\u00f4i ph\u1ee5c m\u00e3 DNA \u0111\u1ec3 t\u1ea1o ra m\u1ed9t gene b\u00ecnh th\u01b0\u1eddng, v\u1edbi ch\u1ee9c n\u0103ng b\u00ecnh th\u01b0\u1eddng, c\u0169ng tr\u1edf n\u00ean kh\u1ea3 thi h\u01a1n”.<\/p>\n

\u0110\u00e1ng ch\u00fa \u00fd, c\u00e1c nh\u00e0 khoa h\u1ecdc cho bi\u1ebft, h\u1ecd c\u00f3 th\u1ec3 \u201ccung c\u1ea5p nh\u1eefng li\u1ec7u ph\u00e1p n\u00e0y cho nh\u1eefng c\u00e1 nh\u00e2n \u0111\u00e3 x\u00e9t nghi\u1ec7m di truy\u1ec1n v\u00e0 ph\u00e1t hi\u1ec7n ra nguy c\u01a1 m\u1eafc b\u1ec7nh ho\u1eb7c ti\u1ebfn tri\u1ec3n th\u00e0nh suy tim b\u1ea5t th\u01b0\u1eddng ch\u1ee9 kh\u00f4ng ph\u1ea3i \u0111\u1ee3i \u0111\u1ebfn l\u00fac b\u1ec7nh nh\u00e2n \u0111\u00e3 ph\u00e1t b\u1ec7nh”.<\/p>\n

“Tr\u01b0\u1edbc \u0111\u00e2y, ch\u00fang t\u00f4i ch\u01b0a bao gi\u1edd c\u00f3 th\u1ec3 \u0111\u01b0a ra c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb nh\u01b0 v\u1eady. Nh\u01b0ng b\u00e2y gi\u1edd, ch\u00fang t\u00f4i bi\u1ebft m\u00ecnh c\u00f3 th\u1ec3 l\u00e0m \u0111\u01b0\u1ee3c v\u00e0 ch\u00fang t\u00f4i \u0111\u1eb7t m\u1ee5c ti\u00eau \u0111\u1ec3 b\u1eaft \u0111\u1ea7u”.<\/p>\n

Ngu\u1ed3n:<\/strong>
\nhttps:\/\/tiasang.com.vn\/khoa-hoc-cong-nghe\/lan-dau-tien-benh-di-truyen-ve-tim-co-the-duoc-chua-khoi\/?fbclid=IwAR3CVysNEGHWn2aYN4ZXuYSiYlII_h32iJK3QVfOq1oKznbeXp33UNjEtDY<\/a><\/p>","protected":false},"excerpt":{"rendered":"

V\u1edbi kho\u1ea3n t\u00e0i tr\u1ee3 tr\u1ecb gi\u00e1 30 tri\u1ec7u b\u1ea3ng Anh, m\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc \u1edf Anh, M\u1ef9 v\u00e0 Singapore \u0111ang h\u1ee3p l\u1ef1c nghi\u00ean c\u1ee9u \u0111\u1ec3 t\u1ea1o ra m\u1ed9t m\u0169i ti\u00eam c\u00f3 kh\u1ea3 n\u0103ng “vi\u1ebft l\u1ea1i” DNA v\u00e0 c\u1ee9u s\u1ed1ng h\u00e0ng ng\u00e0n ng\u01b0\u1eddi tr\u00ean th\u1ebf gi\u1edbi.<\/p>","protected":false},"author":1,"featured_media":802,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/posts\/100"}],"collection":[{"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/comments?post=100"}],"version-history":[{"count":4,"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/posts\/100\/revisions"}],"predecessor-version":[{"id":805,"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/posts\/100\/revisions\/805"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/media\/802"}],"wp:attachment":[{"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/media?parent=100"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/categories?post=100"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/timbamsinhtphcm.vn\/en\/wp-json\/wp\/v2\/tags?post=100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}